Spider-Man

Tobey Maguire

Spider-Man / Peter Parker

Willem Dafoe

Green Goblin / Norman Osborn

Kirsten Dunst

Mary Jane Watson

James Franco

Harry Osborn

Cliff Robertson

Ben Parker

Rosemary Harris

May Parker

J.K. Simmons

J. Jonah Jameson

Joe Manganiello

Flash Thompson

Gerry Becker

Maximilian Fargas

Bill Nunn

Joseph 'Robbie' Robertson

Jack Betts

Henry Balkan

Stanley Anderson

General Slocum

Ron Perkins

Dr. Mendel Stromm

Michael Papajohn

Carjacker

K.K. Dodds

Simkins

Ted Raimi

Hoffman

Bruce Campbell

Ring Announcer

Elizabeth Banks

Miss Brant

John Paxton

Houseman

Tim DeZarn

Philip Watson

Taylor Gilbert

Madeline Watson

Randy Poffo

Bone Saw McGraw

Larry Joshua

Wrestling Promoter

Timothy Patrick Quill

Wrestling Arena Guard

Lisa Danielle

Bone-ette

Natalie T. Yeo

Bone-ette

Erica D. Porter

Bone-ette

Kristen Davidson

Bone-ette

Jason Padgett

Flash's Crony

Shan Omar Huey

Teacher

Don Burgess

فیلم‌بردار

Danny Elfman

آهنگساز

Avi Arad

تهیه‌کننده

Ian Bryce

تهیه‌کننده

Laura Ziskin

تهیه‌کننده

David Koepp

نویسنده

Steven P. Saeta

تهیه‌کننده

Grant Curtis

تهیه‌کننده

Heidi Fugeman

تهیه‌کننده

Sam Raimi

کارگردان

Stan Lee

تهیه‌کننده